With the Hamilton HxSil product series, Hamilton offers two silica based modifications for the reversed phase chromatography.
| Phase | Modification | Particle size / µm | Pore size / Å | pH range | Tmax / °C |
| Hamilton HxSil C18 | C18 | 3, 5 | 110 | 1.5-10 | 60 |
| Hamilton HxSil C8 | C8 | 3, 5 | 110 | 1.5-10 | 60 |