CHIRALPAK HPLC Columns | MZ-Analysentechnik GmbH

Technical Data

Phase name	Chiral selector	Particle size	USP	pH range	Tmax
Chiralpak^® AD	Amylose-tris-(3,5-dimethylphenylcarbamate)	3, 5, 10 µm	L51	2.0-9.0	40 °C
Chiralpak^® AS	Amylose-tris-(S)-α-methylbenzylcarbamate	3, 5, 10 µm	L90	2.0-9.0	40 °C
Chiralpak^® AY	Amylose-tris-(5-chloro-2-methylphenylcarbamate)	3, 5, 10 µm	N/A	2.0-9.0	40 °C
Chiralpak^® AZ	Amylose-tris-(3-chloro-4-methylphenylcarbamate)	3, 5, 10 µm	N/A	2.0-7.0	40 °C
Chiralpak^® IA	Amylose-tris-(3,5-dimethylphenylcarbamate)	1.6, 3, 5, 10 µm	L99	2.0-9.0	40 °C
Chiralpak^® IB	Cellulose-tris-(3,5-dimethylphenylcarbamate)	1.6, 3, 5, 10 µm	N/A	2.0-9.0	40 °C
Chiralpak^® IC	Cellulose-tris-(3,5-dichlorophenylcarbamate)	1.6, 3, 5, 10 µm	N/A	2.0-9.0	40 °C
Chiralpak^® ID	Amylose-tris-(3-chlorophenylcarbamate)	3, 5, 10 µm	N/A	2.0-9.0	40 °C
Chiralpak^® IE	Amylose-tris-(3,5-dichlorophenylcarbamate)	3, 5, 10 µm	N/A	2.0-9.0	40 °C
Chiralpak^® IF	Amylose-tris-(3-chloro-4-methylphenylcarbamate)	3, 5, 10 µm	N/A	2.0-9.0	40 °C
Chiralpak^® IG	Amylose-tris-(3-chloro-5-methylphenylcarbamate)	1.6, 3, 5, 10 µm	N/A	2.0-9.0	40 °C
Chiralpak^® IH	Amylose-tris-((S)-α-methylbenzylcarbamate)	1.6, 3, 5 µm	N/A	2.0-9.0	40 °C
Chiralpak^® Zwix (+)	Quinine combined with(S,S)-trans-Aminocyclo-hexanesulfonic acid	3 µm	N/A	N/A	45 °C
Chiralpak^® Zwix (-)	Quinidine combined with(R,R)-trans-aminocyclo-hexanesulfonic acid	3 µm	N/A	N/A	45 °C
Chiralpak^® AGP	a1-acid glycoprotein	5 µm	L41	4.0-7.0	30 °C
Chiralpak^® CBH	Cellobiohydrolase	5 µm	N/A	4.0-7.0	30 °C
Chiralpak^® HSA	Human serum albumin	5 µm	N/A	5.0-7.0	30 °C
Chiralpak^® QN-AX	9-O-(tert-butylcarbamoyl) quinine	5 µm	N/A	2.0-8.0	40 °C
Chiralpak^® QD-AX	9-O-(tert-butylcarbamoyl) quinidine	5 µm	N/A	2.0-8.0	40 °C
Chiralpak^® MA(+)	N,N-Dioctyl-L-alanine- Cu(II)-complex	3 µm	N/A	N/A	40 °C
Chiralpak^® WH	L-proline - Cu(II)-complex	10 µm	L32	N/A	50 °C

Chiralpak^® immobilised phases (IA, IB, IC, ID, IE, IF and IH) are a newer generation of polysaccharide phases, in which the amylose or cellulose chiral selector has been immobilised on to a wide pore silica matrix. This results in a higher solvent stability compared to the traditional coated phases, which simplifies the method development. Columns for SFC are available.

Chiralpak^® AD, AS, AY and AZ are coated amylose phases and the predecessors to immobilised phases. These materials have limited solvent stability, compared to the newer immobilised phases, due to the solubility of the polymer coating in certain solvents. Chiralpak^® AD and AS phases are well-established phases that are complemented by the newer AY and AZ phases through their alternative selectivity. Columns for SFC are available.

Chiralpak^® Zwix (+) and Zwix (‒) are immobilised zwitterionic stationary phases incorporating both anion- and cation-exchange functional groups. Chiralpak^® Zwix phases exhibit stereoselectivity for zwitterionic compounds, e.g. underivatised amino acids or peptides.

Chiralpak^® AGP, CBH, and HSA are protein-based stationary phases in which the protein is immobilised on to porous spherical silica particles. These columns function in reversed-phase mode, using buffer with low organic content and at moderate pH value.

Chiralpak^® QN-AX and QD-AX are chiral stationary phases for anion exchange chromatography. These are ideal for the separation of chiral acids.

Chiralpak^® MA (+) and WH are chiral stationary phases for ligand exchange chromatography. Chiralpak^® MA (+) uses a proline derivative as chiral selector which is covalently bound to silica particles. Chiralpak^® WH uses a N,N-Dioctyl-L-alanine as chiral selector which is coated to silica particles. They are used in conjunction with an aqueous CuSO₄ eluent and are useful for the separation of amino acids and their derivatives.

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