Chiral Technologies - Daicel / Chiralcel

Chiralcel

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Chiralcel® is the brand name for a variety of traditional "coated" HPLC phases for enantiomer separation from the manufacturer Chiral Technologies (Daicel). The base material of these columns is a spherical silica gel to which a modified cellulose is physically bound as a chiral selector ("Coated CSP"). Compared to the more modern chiral "immobilised" phases, the solvent stability of "coated CSPs" is limited and the use of some solvents as mobile phases is not permitted.

 

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Technical Data

The following nomenclature is used for Chiralcel® phases:

Phase type (particle size)

Series

Example of

10 µm phases

-

Chiralcel® OD

10 µm phases for reversed phase

R-Series

Chiralcel® OD-R

10 µm phases for SFC

10 SFC

Chiralcel® OD-10 SFC

5 µm phases

H-series

Chiralcel® OD-H

5 µm phases for reversed phase

RH-Series

Chiralcel® OD-RH

5 µm phases for SFC

H SFC

Chiralcel® OD-H SFC

3 µm phases

3 series

Chiralcel® OD-3

3 µm phases for reversed phase

3R Series

Chiralcel® OD-3R

3 µm phases for SFC

3 SFC

Chiralcel® OD-3 SFC

Phase name[1]

Chiral selector

Particle size

USP

pH range[2]

Tmax

Chiralcel® OA
Chiralcel® OA-H
Chiralcel® OA-3

Cellulose triacetate

10 µm
5 µm
3 µm

N/A

N/A

40 °C

Chiralcel® OB
Chiralcel® OB-H
Chiralcel® OB-3

Cellulose tribenzoate

10 µm
5 µm
3 µm

N/A

N/A

40 °C

Chiralcel® OC
Chiralcel® OC-H
Chiralcel® OC-3

Cellulose-tris-(phenylcarbamate)

10 µm
5 µm
3 µm

L70

N/A

40 °C

Chiralcel® OD
Chiralcel® OD-H
Chiralcel® OD-3

Cellulose tris-(3,5-dimethylphenylcarbamate)

10 µm
5 µm
3 µm

L40 / L93

2.0-9.0

40 °C

Chiralcel® OF
Chiralcel® OF-H
Chiralcel® OF-3

Cellulose-tris-(4-chlorophenylcarbamate)

10 µm
5 µm
3 µm

N/A

N/A

40 °C

Chiralcel® OG
Chiralcel® OG-H
Chiralcel® OG-3

Cellulose-tris-(4-methylphenylcarbamate)

10 µm
5 µm
3 µm

N/A

N/A

40 °C

Chiralcel® OJ
Chiralcel® OJ-H
Chiralcel® OJ-3

Cellulose-tris-(4-methylbenzoate)

10 µm
5 µm
3 µm

L80

2.0-9.0

40 °C

Chiralcel® OK
Chiralcel® OK-H
Chiralcel® OK-3

Cellulose tricinnamate

10 µm
5 µm
3 µm

N/A

N/A

40 °C

Chiralcel® OX
Chiralcel® OX-H
Chiralcel® OX-3

Cellulose-tris-(4-chloro-3-methylphenylcarbamate)

10 µm
5 µm
3 µm

N/A

2.0-9.0

40 °C

Chiralcel® OZ
Chiralcel® OZ-H
Chiralcel® OZ-3

Cellulose-tris-(3-chloro-4-methylphenylcarbamate)

10 µm
5 µm
3 µm

N/A

2.0-9.0

40 °C

[ 1 ] Columns for reversed-phase and SFC applications are not specified separately


[2 ] The specified pH range only applies to reversed-phase applications

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