Sepax / Monomix

Monomix

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Monomix columns from Sepax include various modifications for special applications. All phases are based on polymers.

With the Monomix Aminodiol and the dT20 Affinity, two modifications are available for affinity chromatography.

The Monomix Core Phase is a core-shell material based on polymers. Various surface modifications and a special pore structure make different interactions possible.

Monomix H2P SAX is a special phase for the determination of surfactants.

Monomix IEX includes various modifications for anion and cation exchange chromatography.

Monomix Mab60-SP is a material with a pore size of 1000Å and cation exchange functionalisation. Therefore this material is suitable for the analysis of antibodies, vaccines, insulin, proteins, nucleic acids and heparin.

Monomix MC-HIC are phases for hydrophobic intercation chromatography. Various modifications are available for different selectivities.

MonomixSEC are materials for size exclusion chromatography. The phases are compatible with many common organic solvents and aqueous buffers.

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Technical Data

Monomix Affinity Chromatography

Phase	Modification	matrix	Particle size	Pore size	pH range	Temperature range
Monomix MC30-Aminodiol	Aminodiol	Hydrophilic polymethacrylate	30 µm	500, 1000 Å	2.0 - 12.0	4 - 40 °C
Monomix dT(20)	Oligo dT20-mer	Hydrophilic polymethacrylate	30 µm	1000 Å	2.0 - 12.0	4 - 65°C

Monomix Core

Phase	Modification Core	Shell modification	Pore size	Exclusion limit	Ion exchange capacity of the core	pH range	Tmax
Monomix Core	Amines	Hydrophilic groups	500 Å 1000 Å	400,000 Da 700,000 Da	80 - 300 µmol Cl^-/mL Medium	2.0 - 13.0	≤40 °C

Monomix H2P SAX

Phase	Modification	Particle size	Ion exchange capacity	pH range	Tmax
Monomix H2P SAX	Mixed-Mode	40 µm	0.5 meq/g	1.0 - 13.0	80 °C

Monomix IEX

Phase	Modification	Particle size	Pore size	Dynamic binding capacity	pH range	Temperature range
Monomix HC-Q	quaternary ammonium	30, 60 µm	500, 1000Å	>100 mg BSA	2.0 - 12.0	≤40 °C
Monomix MC-Q	quaternary ammonium	30, 60 µm	500, 1000Å	>51 mg BSA	2.0 - 12.0	≤40 °C
Monomix HC-DEAE	Diethylaminoethyl	30, 60 µm	500, 1000Å	>90 mg BSA	2.0 - 12.0	≤40 °C
Monomix MC-DEAE	Diethylaminoethyl	30, 60 µm	500, 1000Å	>47 mg BSA	2.0 - 12.0	≤40 °C
Monomix HC-SP	Sulfonic acid	30, 60 µm	500, 1000Å	>105 mg Lysozymes	2.0 - 12.0	≤40 °C
Monomix MC-SP	Sulfonic acid	30, 60 µm	500, 1000Å	>52 mg Lysozymes	2.0 - 12.0	≤40 °C

Monomix Mab60-SP

Phase	Modification	Particle size	Pore size	Dynamic binding capacity	pH range
Monomix Mab60-SP	Sulfonic acid	60 µm	1000 Å	≥60 mg lysozymes / mL medium	1.0 - 14.0

Monomix MC-HIC

Phase	Modification	Particle size	Pore size	Dynamic binding capacity	pH range	Tmax
Monomix MC-HIC Ether	Ether	30 µm 60 µm	1000 Å	>20 mg Lysozymes/mL medium >10 mg Lysozymes/mL medium	2.0 - 13.0	40 °C
Monomix MC-HIC Butyl	C4	30 µm 60 µm	1000 Å	>40 mg Lysozymes/mL medium >20 mg Lysozymes/mL medium	2.0 - 13.0	40 °C
Monomix MC-HIC Phenyl	Phenyl	30 µm 60µm	1000 Å	>45 mg Lysozymes/mL medium >30 mg Lysozymes/mL medium	2.0 - 13.0	40 °C

Monomix SEC

Phase	Particle size	Pore size	Molecular area PEO or PEG	Molecular area Dextran	Molecular range globular protein	pH range	Tmax
Monomix MC10 SEC	10 µm	500 Å 1000 Å	N/A 10,000 - 1,000,000 Da	N/A 40,000 - 1,000,000 Da	N/A 40.000 - 5.000.000	2.0 - 12.0	80 °C
Monomix MC15 SEC	15 µm	500 Å 1000 Å	N/A 10,000 - 1,000,000 Da	N/A 40,000 - 1,000,000 Da	N/A 40.000 - 5.000.000	2.0 - 12.0	80 °C
Monomix MC30 SEC	30 µm	500 Å 1000 Å	N/A 10,000 - 1,000,000 Da	N/A 40,000 - 1,000,000 Da	N/A 40.000 - 5.000.000	2.0 - 12.0	80 °C
Monomix MC60 SEC	60 µm	500 Å 1000 Å	N/A 10,000 - 1,000,000 Da	N/A 40,000 - 1,000,000 Da	N/A 40.000 - 5.000.000	2.0 - 12.0	80 °C

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