Merck Supelco (Sigma-Aldrich) / Astec Chiraldex

Astec Chiraldex

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Astec Chiraldex® are special GC columns, manufactured by Merck-Supelco™ (Sigma-Aldrich™) for the separation of enantiomers. The phases are based on differently modified cyclodextrins as the chiral selector.

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Technical Data

Astec Chiraldex® A-TA:           

  • High selectivity for oxygen containing analytes in the form of alcohols, ketones, acids, aldehydes and lactones
  • It is also highly selective for halogenated compounds.
     

Astec Chiraldex® B-TA:           

  • High selectivity for oxygen containing analytes in the form of alcohols, ketones, acids, aldehydes and lactones
  • It is also highly selective for halogenated compounds.
     

Astec Chiraldex® G-TA:           

  • Highest selectivity for oxygen-containing analytes like alcohols, diols and polyols, amino acids, hydroxy acids, amines as acyl derivatives, amino alcohols, halogens (Cl>Br>F), lactones, furans and pyrans.
  • This phase has been shown to be the most broadly-selective phase for the pharmaceutical industry, especially for the analysis of chiral intermediates and drug studies in various stages of clinical trials.
     

Astec Chiraldex® G-PN:          

  • High selectivity for lactones and aromatic amines. It is also suitable for epoxide separations.
  • Additionally, the analysis of styrene oxide can be accomplished on this phase (this analyte degrades on the TA phases).
     

Astec Chiraldex® B-DP:           

  • Good hydrolytic stability, broad chiral selectivity
  • Excellent for aliphatic and aromatic amines
  • Also good for many aliphatic and some aromatic esters
     

Astec Chiraldex® G-DP:          

  • Enhanced selectivity for both aliphatic and aromatic amines, in additional to aliphatic and some aromatic esters
  • Especially useful for polar racemates
  • Better hydrolytic and thermal stability than the Chiraldex® G-TA
     

Astec Chiraldex® G-BP:          

  • High selectivity for amino acids, amines, and furans
     

Astec Chiraldex® B-DM:          

  • Useful for a number of free acids and bases
  • Able to perform most of the separations done on a beta permethylated phase, but with higher resolution
  • The selectivity of the B-DM covers applications of both the B-PM and B-PH phases, although with superior performance.
     

Astec Chiraldex® G-DM:          

  • Broad chiral selectivity, resolving aliphatic, olefenic, and aromatic enantiomers.
  • It combines the selectivities of the PM and PH phases
     

Astec Chiraldex® B-PM:          

  • General-purpose column used for the separation of acids, alcohols, barbitals, diols, epoxides, esters, hydrocarbons, ketones, lactones and terpenes.
  • Also, some underivatized alcohols and diols as well as some analytes with polar groups, i.e. tertiary amines, show excellent separation.
     

Astec Chiraldex® A-DA:           

  • Good for separations of heterocyclic amines
  • It has different selectivity from other phases and often shows reversal in elution from the PH phases
     

Astec Chiraldex® B-DA:           

  • Chiraldex® B-DA requires that analytes possess a minimum of two ring structures, one of which is unsaturated (aromatic) α, β to the stereogenic center. Examples include fluoxetine, methylphenidate and chloropheniramine.
  • Effective for multi-ring analytes
     

Astec Chiraldex® G-DA:          

  • Good for separations of heterocyclic amines
  • It has different selectivity from other phases and often shows reversal in elution from the PH phases
     

Astec Chiraldex® B-PH:           

  • Show at least some selectivity to a great variety of analytes
  • Effective for saturated analytes with minimal functionality, saturated cyclics and bicyclics
  • This phase often shows a reversal of elution order (enantioreversal) compared to the B-DA phase
Column-Name

Chiral Selector

I.D.

Film thickness

Tmax

Chiraldex® A-TA

2,6-Di-O-pentyl-3-trifluoroacetyl Derivat of α-Cyclodextrin

0.25 mm

0.12 µm

180 °C

Chiraldex® B-TA

2,6-Di-O-pentyl-3-trifluoroacetyl Derivat of β-Cyclodextrin

0.25 mm

0.12 µm

180 °C

Chiraldex® G-TA

2,6-Di-O-pentyl-3-trifluoroacetyl Derivat of γ-Cyclodextrin

0.25 mm

0.12 µm

180 °C

Chiraldex® G-PN

2,6-Di-O-pentyl-3-propionyl Derivat of γ-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® B-DP

2,3-Di-O-propionyl-6-t-butyl silyl Derivat of β-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® G-DP

2,3-Di-O-propionyl-6-t-butyl silyl Derivat of γ-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® G-BP

2,6-Di-O-pentyl-3-butyryl Derivat of γ-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® B-DM

2,3-Di-O-methyl-6-t-butyl silyl Derivat of β-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® G-DM

2,3-Di-O-methyl-6-t-butyl silyl Derivat of γ-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® B-PM

2,3,6-Tri-O-methyl Derivat of β-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® A-DA

2,6-Di-O-pentyl-3-methoxy Derivat of α-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® B-DA

2,6-Di-O-pentyl-3-methoxy Derivat of β-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® G-DA

2,6-Di-O-pentyl-3-methoxy Derivat of γ-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

Chiraldex® B-PH

(S)-2-Hydroxy propyl methyl ether Derivat of β-Cyclodextrin

0.25 mm

0.12 µm

200‒220 °C

[1] Dependent on film thickness and whether you work at constant temperature or with a gradient. 

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