Macherey-Nagel / Nucleosil

Nucleosil

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Nucleosil® is a family of totally porous spherical silicas, manufactured by Macherey-Nagel. They feature a very pure and uniform SiO2 structure and have gained wide acceptance as routine chromatographic packings for very different fields of modern chromatography. Nucleosil® was developed in the 1970s and was one of the first spherical silicas used in HPLC. Nowadays it is a world-renowned HPLC packing. The phases are available with many different modifications.

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Technical Data

Phase-Name

Modification

Particle Size

Pore Size

End-capping

C-Content

USP

Surface

pH-Range

Tmax

Nucleosil® C18

C18

5 µm


3, 5, 7, 10 µm


3, 5, 7, 10 µm


5 µm


7 µm


7 µm

50 Å


100 Å


120 Å


300 Å


500 Å


1000 Å

+

14.5%


15%


11%


6.5%


2%


1%

L1

420 m2/g


350 m2/g


200 m2/g


100 m2/g


35 m2/g


25 m2/g

2.0‒8.0

N/A

Nucleosil® C18 AB

C18

5 µm

100 Å

+

25%

L1

350 m2/g

1.0‒9.0

N/A

Nucleosil® C18 HD

C18

3, 5 µm

100 Å

+

20%

L1

350 m2/g

2.0‒9.0

N/A

Nucleosil® 100-5 C18 PAH

C18

5 µm

100 Å

N/A

N/A

L1

350 m2/g

N/A

N/A

Nucleosil® C8

C8

5, 7, 10 µm


3, 5 µm


5µm

100 Å


120 Å


300 Å

-

8.5%


6.5%


3 %

L7

350 m2/g


200 m2/g


100 m2/g

2.0‒8.0

N/A

Nucleosil® C8 ec

C8

5 µm

100 Å

+

9%

L7

350 m2/g

2.0‒8.0

N/A

Nucleosil® C8 HD

C8

5 µm

100 Å

+

13%

L7

350 m2/g

2.0‒8.0

N/A

Nucleosil® C4

C8

5 µm

120 Å


300 Å

+

4%


2%

L26

200 m2/g


100 m2/g

2.0‒8.0

N/A

Nucleosil® C2

Dimethyl

7 µm

100 Å

-

3.5%

L16

350 m2/g

2.0‒8.0

N/A

Nucleosil® C6H5

Phenylpropyl

5, 7 µm

100 Å

-

8%

L11

350 m2/g

2.0‒8.0

N/A

Nucleosil® CN/CN-RP

Cyanopropyl

5, 10 µm


7 µm

100 Å


120 Å

-

5%


3%

L10

350 m2/g


200 m2/g

2.0‒8.0

N/A

Nucleosil® NH2/ NH2-RP

Aminopropyl

3, 5, 10 µm

100 Å

-

3.5%

L8

350 m2/g

2.0‒8.0

N/A

Nucleosil® OH

Diol

5 µm

100 Å

-

N/A

L20

350 m2/g

2.0‒8.0

N/A

Nucleosil® C18 Nautilus

Polar embedded C18

3, 5 µm

100 Å

+

16%

L60

350 m2/g

2.0‒8.0

N/A

Nucleosil® Protect I

Polar embedded Alcyl

5 µm

100 Å

+

11%

N/A

350 m2/g

2.0‒8.0

N/A

Nucleosil® SB

‒N+(CH3)3 Cl−

5, 10 µm

100 Å

-

10%

L14

350 m2/g

2.0‒8.0

N/A

Nucleosil® Anion II

Quaternary Ammonium

10 µm

300 Å

N/A

N/A

N/A

100 m2/g

2.0‒7.5

N/A

Nucleosil® N(CH3)2

Diethylamino

5 µm

100 Å

-

4%

N/A

350 m2/g

2.0‒8.0

N/A

Nucleosil® SA

Benzenesulfonic acid

5, 10 µm

100 Å

-

6,5%

L9

350 m2/g

2.0‒8.0

N/A

Nucleosil® MPN

C18
C4

5 µm

100 Å


300 Å

N/A

N/A

L1


L26

350 m2/g


100 m2/g

2.0‒8.0

N/A

Nucleosil® PPN

C18

5 µm

100 Å


500 Å

N/A

N/A

L1

350 m2/g


35 m2/g

1.0‒9.0

N/A

Nucleosil® Carbohydrate

Amino

10 µm

N/A

N/A

N/A

L8

N/A

N/A

N/A

Nucleosil® CHIRAL-1

L-Hydroxyproline Cu2+ complex

5 µm

120 Å

N/A

N/A

L32

200 m2/g

N/A

N/A

Nucleosil® CHIRAL-2

N-(3,5-Dinitrobenzoyl)-D-phenylglycin

5 µm

100 Å

N/A

N/A

L36

350 m2/g

N/A

N/A

Nucleosil® CHIRAL-3

N-(3,5-Dinitrobenzoyl)-L-phenylglycin

5 µm

100 Å

N/A

N/A

L36

350 m2/g

N/A

N/A

Nucleosil® SiOH

-

5 µm

50 Å


100 Å

-

-

L3

450 m2/g


350 m2/g

2.0‒8.0

N/A

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