The Mixed-Mode Phases from Dr. Maisch can separate very different substances in one analysis. The phases consist of two different functionalities and are suitable for specific substances.
| Phase | Modification | Particle size / μm | Pore size / Å |
| ReproSil Amide-C16 | Amide, C16 | 5 | N/A |
| ReproSil Mixed-Mode Amino-C18 | NH2, C18 | 3, 5 | N/A |
| ReproSil Mixed-Mode Amino-C8 | NH2, C8 | 3, 5 | N/A |
| ReproSil Mixed-Mode Cyano-C18 | CN, C18 | 5 | N/A |
| ReproSil Mixed-Mode Phenyl-C18 | Ph, C18 | 5, 10 | N/A |
| ReproSil Mixed-Mode C18-Acid | Carboxyl, C18 | 5, 10 | N/A |
| Reprospher 120 SAX | SAX, C8 | 10 | 120 |
| Reprospher 120 SCX | SCX, C8 | 10 | 120 |
| Reprospher 120 C8-Z | C8 without SAX/SCX | 10 | 120 |