Crownpak® HPLC columns from Chiral Technologies (Daicel) use a chiral crown ether as chiral selector, which is coated or immobilised onto a spherical 5 µm silica support. They can be used for the enantiomeric separation of amino acids and other small molecules containing a primary amino group near the chiral centre. The Crownpak® CR(+) column gives the reversed elution order compared to the CR(−) column.
Phase name | Chiral selector | Particle size | USP | pH range | Tmax |
Crownpak CR(+) | Chiral Crown Ether | 5 µm | L66 | 1.0-9.0 | 50 °C |
Crownpak CR(-) | Chiral Crown Ether | 5 µm | L117 | 1.0-9.0 | 50 °C |